| Insert |
DNA: genomic Insert lengths(kb): 1.299999952316284 Gene product: colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog( CD115 antigen, FMS proto-oncogene, macrophage colony stimulating factor I receptor, colony stimulating factor 1 receptor) [FMS] Alleles: A1, B1, B2, A1, B1, B2, A2, A2 |
| Comments |
Restriction digests of the clone give the following sizes (kb): BamHI--5.6; BglII--5.6; PstI--4.3, 1.3. The insert is 3' and adjacent to pSM7C (ATCC 41016) and represents the 3' 1.3 kb of the 3.0 kb v-fms viral oncogene. This probe includes sequences from the tyrosine kinase domain. The probe will detect human c-fms DNA and RNA transcripts. Recorded as not polymorphic by Collaborative Research, meaning either not polymorphic in 0.8% agarose gels, or difficult to work with. |
| References |
Donner L, et al. McDonough feline sarcoma virus: Characterization of the molecularly cloned provirus and its feline oncogene (v-fms). J. Virol. 41: 489-500, 1982. PubMed: 6281462
Hampe A, et al. Nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases. Proc. Natl. Acad. Sci. USA 81: 85-89, 1984. PubMed: 6582485
Barbara Weiffenbach, personal communication
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