Insert contains an internal BamHI site. Restriction digests of the clone give the following sizes (kb): BamHI--3.4, 1.0; EcoRI/HindIII--2.7, 1.8; HindIII--4.5; EcoRI--2.7. 1.8; PstI--3.3, 1.1. DXS42 shows tight linkage with Lowe oculocerebrorenal syndrome (OCRL) in seven families (no recombination was observed between DXS42 and OCRL). This probe was derived from a cosmid containing p43-15a. It is located 7-10 kb from p43-15. |
