| Comments |
Restriction digests of the clone give the following sizes (kb): BamHI--2.8, 1.2; BglI--2.0, 1.2, 0.9; BglI/HindIII--1.4, 1.1, 0.9, 0.7; PvuI--3.0, 1.0; PvuII--2.5, 1.5. Detects germline genomic restriction fragments of the following sizes (kb): EcoRI--8.5; HindIII--13.0; BglII--9.3. Derived from intron 1 about 17 kb 5' to exon 2. |
| References |
Chen SJ, et al. Molecular cloning of a 5' segment of the genomic phl gene defines a new breakpoint cluster regions (bcr2) in Philadelphia-positive acute leukemias. Leukemia 2: 634-641, 1988. PubMed: 3172840
George AL Jr., et al. Assignment of human skeletal muscle sodium channel alpha-subunit gene (SCN4A) to 17q23.1-25.3. Genomics 9: 555-556, 1991. PubMed: 1851726
Chen SJ, et al. Phi+ bcr- acute leukemias: implication of Alu sequences in a chromosomal translocation occurring in the new cluster region within the BCR gene. Oncogene 4: 195-202, 1989. PubMed: 2648256
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