| Comments |
Restriction digests of the clone give the following sizes (kb): EcoRI/HindIII--2.5, 2.05, 0.7, 0.6. An EcoRI/HindIII double digest shows insert fragment sizes of 2.1 and 0.5 kb. Codominant segregation of the PvuII RFLP has been observed in 50 3-generation families. Enzyme(s) not detecting polymorphism: BamHI, BglII, EcoRI, HindIII, MspI, PstI, RsaI, TaqI. |
| References |
Nakamura Y, et al. Localization of the genetic defect in multiple endocrine neoplasia type I within a small region of chromosome 11. Am. J. Hum. Genet. 44: 751-755, 1989. PubMed: 2565085
Holm T, et al. Isolation and mapping of a polymorphic DNA sequence (pTHH126) on chromosome 11 (D11S149). Nucleic Acids Res. 16: 4746, 1988. PubMed: 2898130
Yusuke Nakamura, personal communication
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